Eficácia clínica de uma formulação cosmética contendo vitamina B3 para o tratamento da pele oleosa
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Data
2021
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Edições Universitárias Lusófonas
Resumo
A pele oleosa apresenta necessidades especiais, como o tratamento e a prevenção da acne inflamatória e controle do sebo, sem comprometer a integridade da função barreira e hidratação. Assim, a importância do desenvolvimento de formulações cosméticas específicas e inovadoras para esse tipo de pele, adequadas as suas necessidades, é evidente. Nesse contexto, o objetivo do presente estudo foi a avaliação da eficácia clínica de formulações contendo vitamina B3 para o tratamento da pele oleosa por meio de técnicas de biofísica e análise de imagem. Participantes do sexo feminino (n=40), idade entre 18 e 30 anos, pele oleosa e/ou acne inflamatória foram selecionadas para o estudo e receberam a formulação contendo ou não (veículo) 3% de vitamina B3. Foram avaliados o conteúdo aquoso do estrato córneo, TEWL, conteúdo de sebo e porfirinas e aplicado um questionário da eficácia percebida. A formulação contendo vitamina B3 mostrou redução significativa no conteúdo de sebo e porfirinas. Esses resultados também foram relatados pelas participantes na avaliação da eficácia percebida.A vitamina B3 foi efetiva para a aplicação em formulações para os cuidados da pele oleosa, atuando em parâmetros importantes, como o controle da oleosidade e melhora da aparência da pele. Palavras-chave: cosméticos, Niacinamida, fisiologia da pele, pele oleosa, biofísica e análise de imagem da pele
Oily skin has special needs, as the treatment and prevention of non-inflammatory acne and sebum control, maintaining skin barrier function and hydration. In this context, the importance of the development of specific and innovative cosmetics formulations to to fulfill the needs of this type of skin is evident. In this view, the aim of this study was the evaluation of the clinical efficacy of a cosmetic formulation containing Vitamin B3 in the treatment of oily skin using biophysical and skin imaging techniques. Female volunteers (n=40) between 18 to 30 years old with oily skin and/ or mild inflammatory acne were recruited and received a formulation containing, or not (vehicle), 3% of Vitamin B3. Stratum corneum water content, transepidermal water loss (TEWL), sebum content and quantity of porphyrins were analyzed before (baseline) and after 28 days of application. Finally, an efficacy perception questionnaire was applied at the study end. The formulation with vitamin B3, showed a significant reduction of sebum and porphyrin content. The study participants in the assessment of perceived efficacy also reported these results. The studied formulation with Vitamin B3 was effective for oily skin care, acting on important parameters, such as controlling oiliness and improving skin appearance. Keywords: cosmetics, Niacinamide, skin physiology, oily skin, biophysical and skin imaging
Oily skin has special needs, as the treatment and prevention of non-inflammatory acne and sebum control, maintaining skin barrier function and hydration. In this context, the importance of the development of specific and innovative cosmetics formulations to to fulfill the needs of this type of skin is evident. In this view, the aim of this study was the evaluation of the clinical efficacy of a cosmetic formulation containing Vitamin B3 in the treatment of oily skin using biophysical and skin imaging techniques. Female volunteers (n=40) between 18 to 30 years old with oily skin and/ or mild inflammatory acne were recruited and received a formulation containing, or not (vehicle), 3% of Vitamin B3. Stratum corneum water content, transepidermal water loss (TEWL), sebum content and quantity of porphyrins were analyzed before (baseline) and after 28 days of application. Finally, an efficacy perception questionnaire was applied at the study end. The formulation with vitamin B3, showed a significant reduction of sebum and porphyrin content. The study participants in the assessment of perceived efficacy also reported these results. The studied formulation with Vitamin B3 was effective for oily skin care, acting on important parameters, such as controlling oiliness and improving skin appearance. Keywords: cosmetics, Niacinamide, skin physiology, oily skin, biophysical and skin imaging
Descrição
Biomedical and biopharmaceutical research : jornal de investigação biomédica e biofarmacêutica
Palavras-chave
CIÊNCIAS FARMACÊUTICAS, PRODUTOS COSMÉTICOS, PELE, FISIOLOGIA HUMANA, BIOFÍSICA, PHARMACEUTICAL SCIENCES, COSMETICS, SKIN, HUMAN PHYSIOLOGY, BIOPHYSICS, NIACINAMIDA, NIACINAMIDE