Utilize este identificador para referenciar este registo: http://hdl.handle.net/10437/12738
Título: Enlarged PLIN5-uncoated lipid droplets in inner regions of skeletal muscle type II fibers associate with type 2 diabetes
Autores: Fachada, Vasco
Rahkila, Paavo
Fachada, Nuno
Turpeinen, Tuomas
Kujala, Urho M.
Kainulainen, Heikki
Palavras-chave: BIOLOGIA
LÍPIDOS
DIABETES TIPO 2
MÚSCULOS ESQUELÉTICOS
RESISTÊNCIA À INSULINA
BIOLOGY
LIPIDS
TYPE 2 DIABETES
SKELETAL MUSCLE
INSULIN RESISTANCE
Editora: Elsevier
Citação: Fachada, V., Rahkila, P., Fachada, N., Turpeinen, T., Kujala, U. & Kainulainen, H. (2022). Enlarged PLIN5-uncoated lipid droplets in inner regions of skeletal muscle type II fibers associate with type 2 diabetes. Acta Histochemica, 124(3), 100014. https://doi.org/10.1016/j.acthis.2022.151869
Resumo: Skeletal muscle physiology remains of paramount importance in understanding insulin resistance. Due to its high lipid turnover rates, regulation of intramyocellular lipid droplets (LDs) is a key factor. Perilipin 5 (PLIN5) is one of the most critical agents in such regulation, being often referred as a protector against lipotoxicity and consequent skeletal muscle insulin resistance. We examined area fraction, size, subcellular localization and PLIN5 association of LDs in two fiber types of type 2 diabetic (T2D), obese (OB) and healthy (HC) individuals by means of fluorescence microscopy and image analysis. We found that T2D type II fibers have a significant sub-population of large and internalized LDs, uncoated by PLIN5. Based on this novel result, additional hypotheses for the pathophysiology of skeletal muscle insulin resistance are formulated, together with future research directions. Keywords: Lipid droplets, PLIN5, Type II diabetes, Skeletal muscle, Insulin resistance, Fiber type
Descrição: Acta Histochemica 124 (2022)
URI: https://doi.org/10.1016/j.acthis.2022.151869
http://hdl.handle.net/10437/12738
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