Utilize este identificador para referenciar este registo: http://hdl.handle.net/10437/12144
Título: Multi-enzyme systems in flow chemistry
Autores: Fernandes, Pedro Carlos de Barros
Carvalho, Carla C. C. R. de
Palavras-chave: BIOTECNOLOGIA
BIOQUÍMICA
ENZIMAS
METABOLISMO CELULAR
REAÇÕES QUÍMICAS
BIOTHECNOLOGY
BIOCHEMISTRY
ENZYMES
CELLULAR METABOLISM
CHEMICAL REACTIONS
Editora: MDPI
Resumo: Recent years have witnessed a growing interest in the use of biocatalysts in flow reactors. This merging combines the high selectivity and mild operation conditions typical of biocatalysis with enhanced mass transfer and resource efficiency associated to flow chemistry. Additionally, it provides a sound environment to emulate Nature by mimicking metabolic pathways in living cells and to produce goods through the systematic organization of enzymes towards efficient cascade reactions. Moreover, by enabling the combination of enzymes from different hosts, this approach paves the way for novel pathways. The present review aims to present recent developments within the scope of flow chemistry involving multi-enzymatic cascade reactions. The types of reactors used are briefly addressed. Immobilization methodologies and strategies for the application of the immobilized biocatalysts are presented and discussed. Key aspects related to the use of whole cells in flow chemistry are presented. The combination of chemocatalysis and biocatalysis is also addressed and relevant aspects are highlighted. Challenges faced in the transition from microscale to industrial scale are presented and discussed
Descrição: Publicação: Processes
URI: http://hdl.handle.net/10437/12144
Aparece nas colecções:FE - Artigos de Revistas Internacionais com Arbitragem Científica

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